Check Carefully (1)mifepristone will boost the amount or effect of ketamine by affecting hepatic enzyme CYP2B6 metabolism.
efavirenz will lower the extent or effect of ketamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
apalutamide will minimize the level or impact of ketamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with drugs that happen to be CYP3A4 substrates can result in decrease publicity to those medications.
Coadministration of encorafenib with sensitive CYP3A4 substrates may well bring about enhanced toxicity or diminished efficacy of these brokers.
Stay away from concomitant use of tucatinib with CYP3A substrates, where small focus alterations may possibly lead to severe or life-threatening toxicities. If unavoidable, decrease CYP3A substrate dose Based on product labeling.
Overdose may bring on panic attacks and aggressive habits; rarely seizures, enhanced ICP, and cardiac arrest
mitotane decreases levels of ketamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Mitotane is a robust inducer of cytochrome P-4503A4; check when coadministered with CYP3A4 substrates for probable dosage adjustments.
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Profound sedation, respiratory despair, coma, and Dying may result if coadministered. Reserve concomitant prescribing of these medicines in clients for whom other remedy alternatives are inadequate. Limit dosages and durations to your minimum essential. Check intently for signs of respiratory depression and sedation.
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